TY - GEN 
TI - Ketoconazole in paracoccidioidomycosis: efficacy of prolonged oral therapy
AU - Restrepo Moreno, Ángela
AU - Stevens, D. A.
AU - Leiderman, E.
AU - Fuentes, J.
AU - Arana, A.
AU - Angel, R.
AU - Mejía, G. Gómez, I.
AB - Ketoconazole, a new oral imidazole derivative, was employed for the treatment of five patients with paracoccidioidomycosis. The response was excellent, with objective clinical improvement and healing of both mucocutaneous and pulmonary lesions. Mycological and serological tests, as well as delayed hypersensitivity, were assessed and found to correlate with clinical improvement. Therapy was conducted for 12 months with a dose of 200 mg day in 2 patients; in the remainder the dose was reduced (100 mg day) after the first 6 months and maintained as such for an equal period. No side-effects or toxicity were noted despite prolonged treatment. The advantages of the new therapeutic approach are discussed.
DA - 1980
KW - Paracoccidioidomicosis - Tratamiento
KW - Ketoconazole
PB - Spinger
UR - https://repositorio.accefyn.org.co/handle/001/1058
ER -